Bone-marrow suppression; shock symptom, anaphylaxis; jaundice, hepatic failure, hepatic function disorder; acute renal failure; interstitial pneumonia, pulmonary fibrosis; cardiac failure; disseminated intravascular coagulation (DIC), intestinal perforation, GI hemorrhage, ischemic colitis, colitis; ileus; acute resp distress syndrome; acute pancreatitis; Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), erythema multiforme; cardiac tamponade, pulmonary edema, edema & fluid retention; cardiac infarction, venous thromboembolism; infection, syndrome of inappropriate antidiuretic hormone secretion (SIADH); serious mucositis [eg, stomatitis, vasculitis, peripheral nerve disorder, peripheral motor disorder (eg, feeling of weakness in 4 extremities, & radiation recall phenomenon)].
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